反应详情

温度

80 °C

To a solution of ((2S,3S)-3-(((benzyloxy)carbonyl)amino)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-2-yl)methyl methanesulfonate (6.43 g, 13.4 mmol) in Acetonitrile (44.8 ml) was added ethanolamine (8.13 ml, 134 mmol) followed by DIPEA (7.0 ml, 40 mmol). The solution was heated to 80° C. for 20 h, whereupon it was cooled to rt, diluted with EtOAc, washed with water, dried over Na2SO4 and concentrated in vacuo, afford the title compound (4.47 g, 75%) as a white solid. LCMS: Rf=0.60 min, m/z=444.2 (M+1).

1. temperaturewas cooled to rt
2. washwashed with water
3. dry with materialdried over Na2SO4
4. concentrationconcentrated in vacuo