Sodium Bicarbonate → HCID 118379355, compound

HRID 708510Notes

Reaction equation

HRID 708510 reaction equation
[Cl-:1].[CH:2]([O:15][C:16]([C:18]1([O:21]/[N:22]=[C:23](/[C:48]2[N:49]=[C:50]([NH:53][C:54]([O:56][C:57]([CH3:60])([CH3:59])[CH3:58])=[O:55])[S:51][CH:52]=2)\[C:24]([NH:26][C@@H:27]2[C:30](=[O:31])[NH:29][C@@H:28]2[CH2:32][N:33]2[N:37]=[C:36]([CH2:38][NH:39][CH2:40][C:41]3[CH:42]=[N+:43]([CH3:47])[CH:44]=[CH:45][CH:46]=3)[CH:35]=[N:34]2)=[O:25])[CH2:20][CH2:19]1)=[O:17])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:61]([O-:64])(O)=[O:62].[Na+]>C(Cl)Cl>[Cl-:1].[CH:2]([O:15][C:16]([C:18]1([O:21]/[N:22]=[C:23](/[C:48]2[N:49]=[C:50]([NH:53][C:54]([O:56][C:57]([CH3:60])([CH3:59])[CH3:58])=[O:55])[S:51][CH:52]=2)\[C:24]([NH:26][C@@H:27]2[C:30](=[O:31])[NH:29][C@@H:28]2[CH2:32][N:33]2[N:37]=[C:36]([CH2:38][N:39]([CH2:40][C:41]3[CH:42]=[N+:43]([CH3:47])[CH:44]=[CH:45][CH:46]=3)[C:61]([O:64][C:3]([CH3:8])([CH3:4])[CH3:2])=[O:62])[CH:35]=[N:34]2)=[O:25])[CH2:19][CH2:20]1)=[O:17])([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 118379923HCID 118379923, compound

Product 1

HCID 118379355HCID 118379355, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared in an anologous manner to example 85, step 4 using 3-((((2-(((2R,3S)-3-((Z)-2-((1-((benzhydryloxy)carbonyl)cyclopropoxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-4-oxoazetidin-2-yl)methyl)-2H-1,2,3-triazol-4-yl)methyl)amino)methyl)-1-methylpyridin-1-ium chloride (50 mg, 0.058 mmol), Boc-anhydride (0.027 mL, 0.115 mmol), NaHCO3 (satd aq, 1.22 mL) and DCM (1.15 mL). LCMS: Rt=0.99 min, m/z=921.3 (M+) Method 2m_acidic.

Sources & evidence

ORD record
ord-60d35150060d4504889c1678608323d2
Source dataset
uspto-grants-2015_11
Patent number
US09174978B2

Reaction notes

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