Diisopropylethylamine → HCID 178434055, compound

HRID 708519Notes

Reaction equation

HRID 708519 reaction equation
[NH2:1][CH2:2][C:3]1[C:7]([CH3:8])=[N:6][N:5]([CH2:9][C@@H:10]2[C@H:13]([NH:14][C:15](=[O:31])/[C:16](=[N:23]\[O:24][C:25]3([C:28]([OH:30])=[O:29])[CH2:27][CH2:26]3)/[C:17]3[N:18]=[C:19]([NH2:22])[S:20][CH:21]=3)[C:12](=[O:32])[N:11]2[S:33]([OH:36])(=[O:35])=[O:34])[N:4]=1.[C:37]([O:41][C:42]([NH:44][CH2:45][CH2:46][CH2:47][N:48]([C:56](=[N:62][C:63]([O:65][C:66]([CH3:69])([CH3:68])[CH3:67])=[O:64])N1C=CC=N1)[C:49](=[O:55])[O:50][C:51]([CH3:54])([CH3:53])[CH3:52])=[O:43])([CH3:40])([CH3:39])[CH3:38].CCN(C(C)C)C(C)C>CN(C=O)C>[NH2:22][C:19]1[S:20][CH:21]=[C:17](/[C:16](=[N:23]/[O:24][C:25]2([C:28]([OH:30])=[O:29])[CH2:27][CH2:26]2)/[C:15]([NH:14][C@@H:13]2[C:12](=[O:32])[N:11]([S:33]([OH:36])(=[O:34])=[O:35])[C@@H:10]2[CH2:9][N:5]2[N:4]=[C:3]([CH2:2][NH:1]/[C:56](=[N:62]/[C:63]([O:65][C:66]([CH3:69])([CH3:68])[CH3:67])=[O:64])/[N:48]([C:49]([O:50][C:51]([CH3:52])([CH3:53])[CH3:54])=[O:55])[CH2:47][CH2:46][CH2:45][NH:44][C:42](=[O:43])[O:41][C:37]([CH3:40])([CH3:39])[CH3:38])[C:7]([CH3:8])=[N:6]2)=[O:31])[N:18]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 118379892HCID 118379892, compoundHCID 118380185HCID 118380185, compound

Product 1

HCID 178434055HCID 178434055, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a soln of 1-(((Z)-(2-(((2R,3S)-2-((4-(aminomethyl)-5-methyl-2H-1,2,3-triazol-2-yl)methyl)-4-oxo-1-sulfoazetidin-3-yl)amino)-1-(2-aminothiazol-4-yl)-2-oxoethylidene)amino)oxy)cyclopropanecarboxylic acid (33.9 mg, 0.062 mmol) and tert-butyl (3-((tert-butoxycarbonyl)amino)propyl)(((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate (54.2 mg, 0.116 mmol) in DMF (624 μl) at 0° C. was added DIPEA (32.7 μl, 0.187 mmol). After stirring at rt for 16 h, the solution was concentrated in vacuo and used as such without further purification. LCMS: Rt=0.75 min, m/z=943.7 (M+1) Method 2m_acidic.

Workup

  1. concentrationthe solution was concentrated in vacuo
  2. customsuch without further purification

Sources & evidence

ORD record
ord-ad65fe1d7d214223808eaa45c97a39bf
Source dataset
uspto-grants-2015_11
Patent number
US09174978B2

Reaction notes

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