Hydrochloric Acid → HCID 118098709, compound

HRID 708835Notes

Reaction equation

HRID 708835 reaction equation
C(O[C:9]([N:11]([CH2:13][C:14]1[CH:19]=[C:18]([N+:20]([O-])=O)[CH:17]=[CH:16][C:15]=1[C@@H:23]([CH2:29][CH:30]([F:32])[F:31])[C:24]([O:26][CH2:27][CH3:28])=[O:25])C)=O)C1C=CC=CC=1.Cl>CO.[Pd]>[NH2:20][C:18]1[CH:17]=[CH:16][C:15]([C@@H:23]([CH2:29][CH:30]([F:31])[F:32])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[C:14]([CH2:13][NH:11][CH3:9])[CH:19]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 118098708HCID 118098708, compound

Product 1

HCID 118098709HCID 118098709, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

10D (115 mg, 0.255 mmol) was dissolved in MeOH (5 mL) containing HCl (93 mg, 2.55 mmol). 10% Pd/C was added. The reaction mixture was stirred under a hydrogen balloon for 12 h. Pd/C was removed by filtration and the filtrate was concentrated under reduced pressure to give 10E (93 mg, 0.259 mmol, 101% yield).

Workup

  1. customPd/C was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-47dec25bc5f4420fa28e5c7b043f7086
Source dataset
uspto-grants-2015_11
Patent number
US09174974B2

Reaction notes

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