反应详情

17F (2.566 g, 7.12 mmol) was dissolved in dichloromethane (40 mL), then HCl (4M in dioxane) (10 mL, 40.0 mmol) was added. The reaction mixture was stirred for 1 h at rt. The solvent was removed under reduced pressure, and the residue was dried under high vacuum to give 17G (2.265 g, 6.80 mmol, 95% yield) as an off-white solid. MS (ESI) m/z: 261.1 [M+1]+. 1H NMR: (400 MHz, CD3OD) δ ppm 7.30-7.53 (7H, m), 5.33 (2H, s), 4.07 (2H, s), 2.65 (3H, s).

1. customThe solvent was removed under reduced pressure
2. customthe residue was dried under high vacuum