2,4-Dichloropyrimidine → HCID 57824452, compound

HRID 708964Notes

Reaction equation

HRID 708964 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1)=[O:10]>[Pd]>[Cl:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([C:14]2[CH:15]=[CH:16][C:11]([CH:9]=[O:10])=[CH:12][CH:13]=2)[N:7]=1

Participants

4

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 5910734-Formylphenylboronic Acid

Product 1

HCID 57824452HCID 57824452, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The compound was prepared by palladium-catalyzed arylation of 2,4-dichloropyrimidine and 4-formylphenyl boronic acid: 1H NMR (400 MHz, CDCl3) δ 10.13 (s, 1H), 8.74 (d, J=5.0 Hz, 1H), 8.27 (d, J=7.8 Hz, 2H), 8.04 (d, J=7.9 Hz, 2H), 7.74 (m, 1H); EIMS m/z 218 (M+).

Sources & evidence

ORD record
ord-fcfd23c683fa431087ff8ba2b00c34ca
Source dataset
uspto-grants-2015_11
Patent number
US09179681B2

Reaction notes

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