Isoxazole, 4-(chloromethyl)-3,5-dimethyl- → 5-{[(3,5-Dimethyl-1,2-oxazol-4-yl)methyl]sulfanyl}-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one

HRID 709035Notes

Reaction equation

HRID 709035 reaction equation
C(C1[CH:24]=[CH:23][C:6]([CH2:7][S:8][C:9]2[CH:10]=[C:11]([O:19][CH2:20][O:21][CH3:22])[C:12](=[O:18])[N:13]([CH2:15][O:16][CH3:17])[CH:14]=2)=[CH:5][CH:4]=1)C.CC1C(CCl)=C(C)[O:28][N:27]=1>>[CH3:4][C:5]1[C:6]([CH2:7][S:8][C:9]2[CH:10]=[C:11]([O:19][CH2:20][O:21][CH3:22])[C:12](=[O:18])[N:13]([CH2:15][O:16][CH3:17])[CH:14]=2)=[C:23]([CH3:24])[O:28][N:27]=1

Participants

3

Reactant 2

HCID 88246Isoxazole, 4-(chloromethyl)-3,5-dimethyl-HCID 867315275-[(4-ethylbenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one2×

Product 1

HCID 867315305-{[(3,5-Dimethyl-1,2-oxazol-4-yl)methyl]sulfanyl}-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one

Procedure

Prepared as described for 5-[(4-ethylbenzyl)sulfanyl]-3-(methoxymethoxy)-1-(methoxymethyl)pyridin-2(1H)-one (Intermediate 17) but using 3,5-dimethyl-4-chloromethyl-1,2-oxazole instead of 1-(chloromethyl)-4-ethylbenzene.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b4f888ebae0b40d48c7104b1a137b589
Source dataset
uspto-grants-2015_11
Patent number
US09180122B2

Reaction notes

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