Hydrochloric Acid → HCID 89764462, compound

HRID 709129Notes

Reaction equation

[CH2:1]([NH:3][C:4](=[O:27])[O:5][CH2:6][CH:7]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=1)[CH2:8][NH:9]C(OC(C)(C)C)=O)[CH3:2].[ClH:28]>O1CCOCC1>[ClH:28].[CH2:1]([NH:3][C:4](=[O:27])[O:5][CH2:6][CH:7]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:25])([F:26])[F:24])[CH:18]=1)[CH2:8][NH2:9])[CH3:2]

Participants

Conditions

Temperature: 60 °C

Procedure

105 mg (0.27 mmol) of the compound of Example 19A were dissolved in 2 ml of a 4 N solution of hydrogen chloride in dioxane, and the mixture was stirred at 60° C. until the reaction had gone to completion (about 2 h). The volatile components were then removed on a rotary evaporator and the residue was dried under high vacuum. This gave 91 mg of the title compound in a purity of about 83% according to LC/MS (about 86% of theory); this material was reacted further without further purification.

Workup

customhad gone to completion (about 2 h)
customThe volatile components were then removed on a rotary evaporator
customthe residue was dried under high vacuum
customthis material was reacted further without further purification

Sources & evidence

ORD record: ord-7e162d8e33a54455abd2438b552ddfc8
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09180120B2

Reaction notes

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