反应详情

260 mg (0.72 mmol) of the compound of Example 32A were dissolved in 5 ml of methanol, and 2.87 ml (2.87 mmol) of a 1 M solution of lithium hydroxide in water were added. The mixture was stirred at RT for 1 h, then acidified with 1 N hydrochloric acid and diluted with DMSO. This solution was then purified directly by preparative HLPC [Method 9]. This gave 215 mg (86% of theory) of the title compound.

1. customThis solution was then purified directly by preparative HLPC [Method 9]