反应详情

10 g of (2-hydroxy-4-methoxyphenyl)phenylmethanone (Eusolex® 4360, Merck) are dissolved in 5550 ml of ethyl acetate containing 1 g of 1N NaOH. 10 g of 5% Rh/C catalyst (50% of water) are subsequently added. The hydrogenation is carried out using hydrogen 3.0 at 40° C. and a pressure of 5 bar. When the hydrogenation is complete, the catalyst is separated off by filtration. The solution obtained is transferred into the separating funnel, and the phases are separated. The aqueous phase is extracted with ethyl acetate. The combined organic phases are washed with water, subsequently dried over sodium sulfate, filtered and evaporated in a rotary evaporator, giving 7.8 g of product as white solid (cis and trans isomer mixture).

1. customat 40° C.
2. customthe catalyst is separated off by filtration
3. customThe solution obtained
4. customthe phases are separated
5. extractionThe aqueous phase is extracted with ethyl acetate
6. washThe combined organic phases are washed with water
7. dry with materialsubsequently dried over sodium sulfate
8. filtrationfiltered
9. customevaporated in a rotary evaporator