Isatin → HCID 68767389, compound

HRID 709387Notes

Reaction equation

HRID 709387 reaction equation
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=O)[C:2]1=[O:3].C([O-])(=[O:14])C.[Na+].[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](O)=[O:27])=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[C:26](=[O:27])[NH:1][C:11]3[C:6]([C:4]=2[C:2]([OH:14])=[O:3])=[CH:7][CH:8]=[CH:9][CH:10]=3)=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 7054IsatinHCID 76904-Methoxyphenylacetic AcidHCID 517045Sodium Acetate

Product 1

HCID 68767389HCID 68767389, compound

Conditions

Temperature
175 °C

Procedure

7.5 mmol of isatin (III), 1.875 mmol of sodium acetate, and 13.125 mmol p-methoxyphenylacetic acid were mixed, heated to 150-200° C. and refluxed for 1-5 h. The reaction was finished by TLC detection. The reaction solution was washed with petroleum ether and acetone successively. After separated by column chromatography, the title compound was obtained.

Workup

  1. temperaturerefluxed for 1-5 h
  2. washThe reaction solution was washed with petroleum ether and acetone successively
  3. customAfter separated by column chromatography

Sources & evidence

ORD record
ord-ec545ff4112c46a3acc19e617e8c754c
Source dataset
uspto-grants-2015_11
Patent number
US09181193B2

Reaction notes

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