反应详情

温度

130 °C

Under a nitrogen atmosphere, to a solution of ethyl 3-cyclopropyl-3-(2-methoxypyridin-4-yl)propanoate (4.17 g) in DMF (10 mL) was added pyridinium chloride (19.3 g), and the mixture was stirred at 130° C. for 15 min. Ethyl acetate was added to the reaction mixture at 0° C., and the resulting white precipitate was filtered off. The solvent in the filtrate was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (3.61 g) as a yellow oil.

1. filtrationthe resulting white precipitate was filtered off
2. customThe solvent in the filtrate was evaporated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (methanol/ethyl acetate)