反应详情

Under a nitrogen atmosphere, to a suspension of lithium aluminum hydride (74 mg) in THF (9.7 mL) was added dropwise a solution of methyl 6-(2-fluoro-5-methoxyphenyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)nicotinate (466 mg) in THF (3.2 ml) at 0° C., and the mixture was stirred for 1 hr. Sodium sulfate decahydrate was added by small portions, and the mixture was further stirred at room temperature for 1 hr. The reaction mixture was filtered, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (193 mg) as a colorless gummy substance.

1. stirringthe mixture was further stirred at room temperature for 1 hr
2. filtrationThe reaction mixture was filtered
3. customthe solvent was evaporated under reduced pressure
4. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)