反应详情

温度

100 °C

Under a nitrogen atmosphere, to a solution of methyl 5-(2-cyanoethyl)-6-methoxynicotinate (589 mg) in DMF (10 mL) was added pyridinium chloride (3.01 g), and the mixture was stirred at 100° C. for 4 hr. To the reaction mixture was added THF at 0° C., and the resulting precipitate was removed by filtration. The solvent in the filtrate was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (479 mg) as white crystals.

1. customthe resulting precipitate was removed by filtration
2. customThe solvent in the filtrate was evaporated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)