反应详情

温度

50 °C

To a DMF (1.0 mL) solution of the compound (32.5 mg) obtained in Example 9-(6) and phenol (13 mg), K2CO3 (37 mg) was added and the mixture was stirred at 50° C. for 3.5 hours. The reaction mixture was added to water (20 mL) and the organic layer extracted with AcOEt (20 mL×2) was dried (MgSO4), filtered and concentrated to give a crude product, which was further purified by silica gel chromatography (AcOEt/hexane) to give the titled compound (31.6 mg, colorless amorphous.)

1. extractionthe organic layer extracted with AcOEt (20 mL×2)
2. dry with materialwas dried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated
5. customto give a crude product, which
6. customwas further purified by silica gel chromatography (AcOEt/hexane)