反应详情

温度

90 °C

Intermediate 5 (1 g, 3.4 mmol) and 2-Chloro-5-fluoropyrimidine was dissolved in isopropanol (20 ml) and added N,N-diisopropylethyl amine (2.4 ml). This mixture was stirred at 90° C. for 90 mins. Isopropanol was removed on rotavapour to obtain a residue. Work up (EtOAc/H2O) followed by purification on combiflash using a gradient mixture of EtOAc and Petether (7:93) as eluent afforded the titled compound as a pink solid.

1. customIsopropanol was removed on rotavapour
2. customto obtain a residue
3. customfollowed by purification on combiflash
4. additiona gradient mixture of EtOAc and Petether (7:93) as eluent