4-Methoxybenzylamine → HCID 178490830, compound

HRID 710506Notes

Reaction equation

HRID 710506 reaction equation
O1[CH:5]=[N:4][N:3]=[C:2]1[C:6]1[CH:14]=[CH:13][C:9]2[N:10]=[CH:11][NH:12][C:8]=2[CH:7]=1.[CH3:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH2:22])=[CH:19][CH:18]=1>>[CH3:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][N:22]2[CH:5]=[N:4][N:3]=[C:2]2[C:6]2[CH:14]=[CH:13][C:9]3[NH:10][CH:11]=[N:12][C:8]=3[CH:7]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 754524-MethoxybenzylamineHCID 58433284HCID 58433284, compound

Product 1

HCID 178490830HCID 178490830, compound

Procedure

The compound was synthesized starting from 5-(1,3,4-oxadiazol-2-yl)benzimidazole (186 mg, 1 mmol) and 4-methoxybenzylamine (0.5 ml) as described above; yield: 0.083 g (27.2%); MS m/z: 306.4 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.66 (s, 3H); 5.29 (s, 2H); 6.80-6.83 (m, 2H); 6.95-6.97 (m, 2H); 7.61 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 7.82 (d, 1H, 3J=8.7 Hz); 7.91 (d, 1H, 4J=1.7 Hz); 8.73 (s, 1H); 8.96 (s, 1H); HPLC (METHOD [A]): it 8.18 min (99.6%)

Workup

  1. customThe compound was synthesized
  2. customit 8.18 min (99.6%)

Sources & evidence

ORD record
ord-199c9df3e19543c1972ebb32546aeaea
Source dataset
uspto-grants-2015_11
Patent number
US09181233B2

Reaction notes

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