Phosphorus oxychloride → HCID 178492790, compound

HRID 710541Notes

Reaction equation

HRID 710541 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:11][CH2:12][C:13](O)=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[N:16]1[C:20]2[CH:21]=[CH:22][C:23]([C:25]([NH:27][NH2:28])=O)=[CH:24][C:19]=2[NH:18][CH:17]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:38])=CC=1.O=P(Cl)(Cl)Cl>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:11][CH2:12][C:13]2[S:38][C:25]([C:23]3[CH:22]=[CH:21][C:20]4[NH:16][CH:17]=[N:18][C:19]=4[CH:24]=3)=[N:27][N:28]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

5

Reactant 4

HCID 24813Phosphorus oxychlorideHCID 87949Lawesson's reagentHCID 72503895735-63-0HCID 166371191H-benzimidazole-5-carbohydrazide

Product 1

HCID 178492790HCID 178492790, compound

Procedure

The compound was synthesized starting from (3,4-dimethoxyphenylthio)acetic acid (229 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol), Lawesson's reagent (606 mg; 1.5 mmol) and POCl3 (0.137 ml; 1.5 mmol) as described in method 3; yield: 0.042 g (10.9%);

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-2452105ab5d94164a290b7480bd7cd96
Source dataset
uspto-grants-2015_11
Patent number
US09181233B2

Reaction notes

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