反应详情

To a solution of 6-chloro-4-(methylamino)pyridine-3-carboxaldehyde (3.41 g, 20 mmol) in THF (120 mL) was added (carbethoxymethylene)triphenylphosphorane (8.35 g, 24 mmol). The mixture was heated at reflux for 16 h, and was then cooled and concentrated. The residue was chromatographed on silica gel (12% ethyl acetate in hexanes eluant) to provide the title compound. MS (m/z) 241.0 (M+1).

1. temperatureThe mixture was heated
2. temperatureat reflux for 16 h
3. temperaturewas then cooled
4. concentrationconcentrated
5. customThe residue was chromatographed on silica gel (12% ethyl acetate in hexanes eluant)