m-Chloroperbenzoic acid → HCID 72700242, compound

HRID 710606Notes

Reaction equation

HRID 710606 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[C:8](=[O:31])[C:9]3[CH:30]=[CH:29][CH:28]=[N:27][C:10]=3[N:11]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[C:20][C:21]4[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=4)[CH:14]=3)[N:12]=2)=[O:6])[CH2:3][CH2:2]1.ClC1C=C(C=CC=1)C(OO)=[O:37]>ClCCl>[CH:1]1([NH:4][C:5]([C:7]2[C:8](=[O:31])[C:9]3[CH:30]=[CH:29][CH:28]=[N:27][C:10]=3[N:11]([C:13]3[CH:14]=[C:15]([C:19]#[C:20][C:21]4[CH:22]=[N+:23]([O-:37])[CH:24]=[CH:25][CH:26]=4)[CH:16]=[CH:17][CH:18]=3)[N:12]=2)=[O:6])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 72700164HCID 72700164, compound

Product 1

HCID 72700242HCID 72700242, compoundYield 17.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-cyclopropyl-4-oxo-1-[3-(pyridin-3-ylethynyl)phenyl]-1,4-dihydropyridino[2,3-c]p yridazine-3-formamide (0.15 g, 0.36 mmol) was dissolved in 50 mL of dichloromethane solution, m-chloroperoxybenzoic acid (0.062 g, 0.36 mmol) was added and reacted at room temperature. After reaction was complete, separation was purified by liquid preparation chromatography column to obtain product 27 mg.

Workup

  1. customreacted at room temperature
  2. customAfter reaction
  3. customseparation
  4. customwas purified by liquid preparation chromatography column

Sources & evidence

ORD record
ord-e55733d5f6a541de9dd9d04466e70487
Source dataset
uspto-grants-2015_11
Patent number
US09181244B1

Reaction notes

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