Hydrochloric Acid → HCID 118492323, compound

HRID 710609Notes

Reaction equation

HRID 710609 reaction equation
[O:1]=[C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[N:6][N:5]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([S:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)[CH:14]=2)[C:4]2[N:26]=[CH:27][CH:28]=[CH:29][C:3]1=2.[OH-].[K+].Cl>CO>[O:1]=[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[N:6][N:5]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([S:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)[CH:14]=2)[C:4]2[N:26]=[CH:27][CH:28]=[CH:29][C:3]1=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 118492325HCID 118492325, compound

Product 1

HCID 118492323HCID 118492323, compoundYield 17.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 4-oxo-1-(3-(pyridin-3-ylthio)phenyl)-1,4-dihydropyridino[2,3-c]pyridazine-3-carboxylate (1.2 g, 3 mmol) was dispersed in 100 ml of methanol, KOH (840 mg, 15 mmol) was added, reacted at 40° C. for 4 h. The reaction solution was regulated with hydrochloric acid to pH 7, precipitated out solid, suction filtrated and dried to obtain an object product 200 mg.

Workup

  1. customreacted at 40° C. for 4 h
  2. customprecipitated out solid, suction
  3. filtrationfiltrated
  4. customdried

Sources & evidence

ORD record
ord-395d9459a19041f6b8fb9f601d37dc14
Source dataset
uspto-grants-2015_11
Patent number
US09181244B1

Reaction notes

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