1-(2-Bromoethyl)-4-chlorobenzene → 5-(4-chlorophenethyl)-7-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole

HRID 710770Notes

Reaction equation

HRID 710770 reaction equation
Br[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][CH:5]=1.Cl.[Cl:12][C:13]1[CH:14]=[C:15]([NH:19]N)[CH:16]=[CH:17][CH:18]=1.[CH3:21][N:22]1[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]1>C(N(CC)CC)C>[Cl:10][C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][N:19]2[C:15]3[CH:14]=[C:13]([Cl:12])[CH:18]=[CH:17][C:16]=3[C:24]3[CH2:23][N:22]([CH3:21])[CH2:27][CH2:26][C:25]2=3)=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 230291-(2-Bromoethyl)-4-chlorobenzeneHCID 740491-Methyl-4-piperidoneHCID 75331m-Chlorophenylhydrazine hydrochloride

Product 1

HCID 578762715-(4-chlorophenethyl)-7-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound is prepared by following Method 8 by using 1-(2-bromoethyl)-4-chlorobenzene, 3-chlorophenylhydrazine hydrochloride, triethylamine and N-methyl-4-piperidone

Sources & evidence

ORD record
ord-072695c4e1f248d1a8c8ac046220c56d
Source dataset
uspto-grants-2015_11
Patent number
US09181240B2

Reaction notes

Loading…