反应详情

温度

70 °C

tert-Butyl(2-bromoethyl)carbamate (5.00 g, 23.5 mmol) was stirred under an argon atmosphere at room temperature with acetonitrile (74 mL). Then, N-hydroxyphthalimide (Pht-OH, 3.83 g) and triethylamine (5.64 g) were added, followed by stirring the reaction mixture at 70° C. for 24 hours. After completion of the reaction, the reaction solution was concentrated, followed by diluting with ethyl acetate and washing with 0.5M hydrochloric acid and saturated sodium bicarbonate aqueous solution, and the organic layer was dried over magnesium sulfate, to the residue resulting from distilling off the solvent under reduced pressure was added ethyl acetate (10 ml), followed by adding hexane, thereby 4.72 g of the title compound was afforded (yield 65.7%). The instrumental data were consistent with those of the compound of Reference Example 7.

1. customAfter completion of the reaction
2. concentrationthe reaction solution was concentrated
3. additionby diluting with ethyl acetate
4. washwashing with 0.5M hydrochloric acid and saturated sodium bicarbonate aqueous solution
5. dry with materialthe organic layer was dried over magnesium sulfate, to the residue
6. customresulting
7. distillationfrom distilling off the solvent under reduced pressure
8. additionwas added ethyl acetate (10 ml)
9. additionby adding hexane