2-Bromopyridine → HCID 817760, compound

HRID 711392Notes

Reaction equation

HRID 711392 reaction equation
[C:1]1([S:7][C:8](Cl)(Cl)Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[C:13]1[CH:18]=[CH:17][CH:16]=C[N:14]=1>C(N)=O>[C:1]1([S:7][C:8]2[CH:16]=[CH:17][CH:18]=[CH:13][N:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 79732-BromopyridineHCID 23273522[(Trichloromethyl)sulfanyl]benzene

Product 1

HCID 817760HCID 817760, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 713FormamideSolvent

Conditions

Temperature
75 °C

Procedure

A solution of phenyl(trichloromethyl)sulfane (0.25 g, 1.099 mmol) in formamide (16.40 ml), was degassed with nitrogen and treated with 2-bromopyridine (0.115 ml, 1.209 mmol). The reaction solution was heated at 75° C. overnight. Gas Chromatography-Mass Spectrometry (GCMS) indicates a yield of 81% of 2-(phenylthio)pyridine, and a 7% byproduct of disulfide.

Sources & evidence

ORD record
ord-d013315b44224a8b9d33d721f998ca36
Source dataset
uspto-grants-2015_11
Patent number
US09181270B2

Reaction notes

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