Hydrochloric Acid → HCID 66607849, compound

HRID 71140Notes

Reaction equation

HRID 71140 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15]([NH:17][NH:18]C(OC(C)(C)C)=O)=[O:16])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.[ClH:26]>C(OCC)(=O)C>[ClH:26].[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1)[C:15]([NH:17][NH2:18])=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66608673tert-butyl 2-{[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]carbonyl}hydrazinecarboxylate

Product 1

HCID 66607849HCID 66607849, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a mixture of tert-butyl 2-{[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]carbonyl}hydrazinecarboxylate (8.00 g) in ethyl acetate (50 mL) was added hydrogen chloride (4M ethyl acetate solution, 100 mL), and the mixture was stirred at room temperature overnight. Ethyl acetate was added to the reaction mixture, and the precipitate was collected by filtration. The solid was recrystallized from methanol/ethyl acetate to give the title compound (5.94 g).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customThe solid was recrystallized from methanol/ethyl acetate

Sources & evidence

ORD record
ord-d82811af26574c32ae8286a7291a7dfc
Source dataset
uspto-grants-2014_09
Patent number
US08822699B2

Reaction notes

Loading…