反应详情

To a suspension of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid (5 g) in THF (60 mL) was added N,N′-carbonyldiimidazole (6.98 g) at room temperature, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was cooled to −10° C., hydrazine monohydrate (10.44 mL) was added, and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure, and water was added. The precipitated solid was collected by filtration to give the title compound (0.70 g).

1. temperatureThe reaction mixture was cooled to −10° C.
2. stirringthe mixture was stirred at room temperature for 2 hr
3. customThe solvent was evaporated under reduced pressure, and water
4. additionwas added
5. filtrationThe precipitated solid was collected by filtration