反应详情

温度

90 °C

A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.47 g, 2.2 mmol) (Example 1, step 2), trans-4-aminocyclohexanol (from Aldrich, 0.50 g, 4.4 mmol) and N,N-diisopropylethylamine (1.1 mL, 6.6 mmol) in isopropyl alcohol (7.4 mL) was heated at 90° C. for 2 h. The reaction mixture was concentrated and purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product (0.266 g, 41%). LCMS calculated for C13H16N3O3S (M+H)+: m/z=294.1. Found: 294.0.

1. concentrationThe reaction mixture was concentrated
2. custompurified on silica gel (eluting with 0 to 5% MeOH in dichloromethane)