反应详情

温度

90 °C

A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.10 g, 0.46 mmol), cis-4-(1H-1,2,4-triazol-1-yl)cyclohexanamine TFA salt (0.10 g, 0.60 mmol) and N,N-diisopropylethylamine (0.40 mL, 2.3 mmol) in isopropyl alcohol (1.0 mL) was heated at 90° C. for 2 h. The resulting mixture was concentrated and purified on silica gel (eluting with 0 to 10% EtOAc in dichloromethane) to give the desired product (32 mg, 20%). LCMS calculated for C15H17N6O2S (M+H)+: m/z=345.1. Found: 345.0.

1. concentrationThe resulting mixture was concentrated
2. custompurified on silica gel (eluting with 0 to 10% EtOAc in dichloromethane)