Hydrazine hydrate (1:1) → HCID 66608309, compound

HRID 71197Notes

Reaction equation

HRID 71197 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][N:5]([C:7]2[CH:16]=[CH:15][C:10]([C:11](OC)=[O:12])=[CH:9][C:8]=2[O:17][CH3:18])[CH:6]=1.O.[NH2:20][NH2:21]>CO>[Cl:1][C:2]1[N:3]=[CH:4][N:5]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([NH:20][NH2:21])=[O:12])=[CH:9][C:8]=2[O:17][CH3:18])[CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 66608175methyl 4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzoate

Product 1

HCID 66608309HCID 66608309, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a mixture of methyl 4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzoate (25.5 mg) in methanol (1 mL) was added hydrazine monohydrate (0.019 mL) at room temperature, the mixture was stirred at 60° C. overnight, and the solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (12.7 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-f7d3b1b7445d4dfea80014406585c417
Source dataset
uspto-grants-2014_09
Patent number
US08822699B2

Reaction notes

Loading…