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HRID712125

反应详情

EQUATION

反应方程式

HRID 712125 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：O=[N+]([O-])c1cnc2ccsc2c1Cl
HCID14207950

7-Chloro-6-nitrothieno[3,2-b]pyridine

C7H3ClN2O2S

结构：CC(C)(C)OC(=O)NC[C@H]1CC[C@H](N)CC1
HCID178453642

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC[C@H]1CC[C@H](Nc2c([N+](=O)[O-])cnc3ccsc23)CC1
HCID178453640

未命名化合物

收率 78.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

CONDITIONS

反应条件

温度
90 °C

PROCEDURE

实验过程

A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (220 mg, 1.0 mmol), tert-butyl [(trans-4-aminocyclohexyl)methyl]carbamate (250 mg, 1.1 mmol) and triethylamine (0.43 mL, 3.1 mmol) in isopropyl alcohol (8 mL) was heated at 90° C. for 2 h. The solvent was removed and the resulting residue was purified by flash chromatography (0-80% EtOAc/Hexanes) to give the desired product (0.32 g, 77%). LCMS calculated for C19H27N4O4S (M+H)+: m/z=407.2. Found: 407.0.

WORKUP

后处理

  1. customThe solvent was removed
  2. customthe resulting residue was purified by flash chromatography (0-80% EtOAc/Hexanes)