反应详情

温度

70 °C

To a solution of 2,6-dibromopyridin-4-amine in THF (250 mL) was added benzoylisothiocyanate (3.50 mL, 26.0 mmol)) and the resulting reaction mixture heated to 70° C. for 16 h. A further 1.50 mL (11.20 mmol) of benzoylisothiocyanate was added to complete the reaction and the reaction stirred at 70° C. for 16 h. After completion (by TLC), the solvent was distilled under reduced pressure, the residue treated with 10% MeOH-ether solution then filtered to obtain the desired product as a yellow solid (7.60 g, 85%).

1. customthe resulting reaction mixture
2. customthe reaction
3. distillationAfter completion (by TLC), the solvent was distilled under reduced pressure
4. additionthe residue treated with 10% MeOH-ether solution
5. filtrationthen filtered