Methanol → 1-Methyloctahydropyrrolo[3,4-b]pyridine

HRID 712460Notes

Reaction equation

HRID 712460 reaction equation
C([N:8]1[CH2:16][CH:15]2[CH:10]([N:11]([CH3:17])[CH2:12][CH2:13][CH2:14]2)[CH2:9]1)C1C=CC=CC=1.CO>[OH-].[OH-].[Pd+2].CCOC(C)=O>[CH3:17][N:11]1[CH2:12][CH2:13][CH2:14][CH:15]2[CH2:16][NH:8][CH2:9][CH:10]12

Participants

5

Reactant 2

HCID 887MethanolHCID 150700086-Benzyl-1-methyloctahydropyrrolo[3,4-b]pyridine

Product 1

HCID 150700091-Methyloctahydropyrrolo[3,4-b]pyridine

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 6-benzyl-1-methyloctahydro-1H-pyrrolo[3,4-b]pyridine (2.00 g) in the mixture solvent of MeOH and EtOAc was added a catalytic amount of 20% Pd(OH)2/C. The reaction mixture was stirred for 2 h at room temperature under H2. The resulted mixture was filtered and the filtrate was concentrated to in vacuo to give the crude product, which was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 141.2 (M+1).

Workup

  1. filtrationThe resulted mixture was filtered
  2. concentrationthe filtrate was concentrated to in vacuo

Sources & evidence

ORD record
ord-ff4d879998284d0fac793ecf4944ea3c
Source dataset
uspto-grants-2015_11
Patent number
US09181277B2

Reaction notes

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