Hydrochloric Acid → HCID 86729510, compound

HRID 712509Notes

Reaction equation

HRID 712509 reaction equation
[CH3:1][N:2]1[CH:17]([CH3:18])[C:5]2[CH2:6][N:7](C(OC(C)(C)C)=O)[CH2:8][CH2:9][C:4]=2[NH:3]1.[ClH:19]>CO.CCOC(C)=O>[ClH:19].[CH3:1][N:2]1[C:17]([CH3:18])=[C:5]2[CH2:6][NH:7][CH2:8][CH2:9][C:4]2=[N:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86729511HCID 86729511, compound

Product 1

HCID 86729510HCID 86729510, compoundYield 91.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl 2,3-dimethyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate (3.0 g) in MeOH was added a solution of HCl in EtOAc (3.0 M). White solid was precipitated out after 3.0 h reaction. The resulted mixture was filtered and the residue was dried to give the title compound as a white solid (2.10 g, 91.90%). The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 152.21 (M+1).

Workup

  1. customWhite solid was precipitated out after 3.0 h
  2. customreaction
  3. filtrationThe resulted mixture was filtered
  4. customthe residue was dried

Sources & evidence

ORD record
ord-846328f4b4dc47138979b1f4a638785a
Source dataset
uspto-grants-2015_11
Patent number
US09181277B2

Reaction notes

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