HCID 86729513, compound → HCID 86729515, compound

HRID 712514Notes

Reaction equation

HRID 712514 reaction equation
[O:1]1[C@@H:6]2[CH2:7][N:8](C(OCC3C=CC=CC=3)=O)[CH2:9][C@H:5]2[O:4][CH2:3][CH2:2]1>C1COCC1.[Pd]>[O:1]1[C@@H:6]2[CH2:7][NH:8][CH2:9][C@H:5]2[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 86729513HCID 86729513, compound

Product 1

HCID 86729515HCID 86729515, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of (4aR,7aR)-benzyl tetrahydro-2H-[1,4]dioxino[2,3-c]pyrrole-6(3H)-carboxylate (140.0 mg, 0.53 mmol) and 10% Pd/C (0.56 mg, 0.053 mmol) in THF (6 mL) was stirred for 5.0 h at 50° C. The resulted mixture was filtered. The filtrate was concentrated in vacuo and the residue was used for the next step without further purification.

Workup

  1. filtrationThe resulted mixture was filtered
  2. concentrationThe filtrate was concentrated in vacuo
  3. customthe residue was used for the next step without further purification

Sources & evidence

ORD record
ord-9d7a31be69cb4c25a0bccc9303d6d576
Source dataset
uspto-grants-2015_11
Patent number
US09181277B2

Reaction notes

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