反应详情

To a solution of (3-bromo-pyridin-4-yl)-methanol (300 mg, 1.6 mmol) in THF (50 mL) at 0° C. is added 60% NaH (96 mg, 2.4 mmol). Then the mixture is stirred at room temperature for 30 min. MeI (270 mg, 1.9 mmol) is added to the mixture at 0° C. and again the mixture is stirred at room temperature for 4 hrs. Then the reaction is quenched with saturated NH4Cl aqueous solution and the mixture is extracted with EtOAc. The organic layer is separated, dried and concentrated to give the crude product. Purification by prep-TLC affords 274 mg of 3-bromo-4-methoxymethyl-pyridine.

1. stirringagain the mixture is stirred at room temperature for 4 hrs
2. customThen the reaction is quenched with saturated NH4Cl aqueous solution
3. extractionthe mixture is extracted with EtOAc
4. customThe organic layer is separated
5. customdried
6. concentrationconcentrated
7. customto give the crude product
8. customPurification