Lithium Hydroxide → HCID 131733992, compound

HRID 712858Notes

Reaction equation

[CH3:1][C@:2]1([C:18]([O:20]C)=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1.[Li+:22].[OH-]>>[CH3:1][C@:2]1([C:18]([O-:20])=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:15])([F:17])[F:16])=[CH:10][CH:9]=1.[Li+:22]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 71204723HCID 71204723, compound

Product 1

HCID 131733992HCID 131733992, compound

Procedure

The title compound (D113) (42 mg) was prepared according to the general procedure for esters hydrolysis (Method A) starting from (R)-methyl 2-methyl-1-(4-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate (D80) (50 mg). (LiOH: 3 eq; Reaction time: 18 hrs; RT)

Sources & evidence

ORD record: ord-1aa536e840fd4343abee18f2c12c5f4d
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181279B2

Reaction notes

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