Lithium Hydroxide → HCID 71186520, compound

HRID 712899Notes

Reaction equation

[F:1][C:2]([F:35])([F:34])[C:3]1[N:8]=[CH:7][C:6]([CH2:9][N:10]2[CH2:17][CH2:16][C:13]3([CH2:15][CH2:14]3)[CH2:12][CH:11]2[C:18]([NH:20][C:21]2([C:24]3[CH:33]=[CH:32][C:27]([C:28]([O:30]C)=[O:29])=[CH:26][CH:25]=3)[CH2:23][CH2:22]2)=[O:19])=[CH:5][CH:4]=1.[Li+].[OH-]>>[F:35][C:2]([F:1])([F:34])[C:3]1[N:8]=[CH:7][C:6]([CH2:9][N:10]2[CH2:17][CH2:16][C:13]3([CH2:15][CH2:14]3)[CH2:12][CH:11]2[C:18]([NH:20][C:21]2([C:24]3[CH:33]=[CH:32][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=3)[CH2:22][CH2:23]2)=[O:19])=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 71186482HCID 71186482, compound

Product 1

HCID 71186520HCID 71186520, compoundYield 76.7%

Procedure

The title compound (E8) (35 mg) was prepared according to the general procedure for esters hydrolysis (Method D) starting from methyl 4-(1-(6-((6-(trifluoromethyl)pyridin-3-yl)methyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoate (D124) (47 mg). (LiOH: 4 eq; Reaction time: 5 hrs; RT)

Sources & evidence

ORD record: ord-cc878bbf69a943a09b53e733043d8296
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181279B2

Reaction notes

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