Lithium hydroxide, monohydrate → HCID 71186491, compound

HRID 712900Notes

Reaction equation

HRID 712900 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][CH:33]=1)[CH2:6][N:7]1[CH2:14][CH2:13][C:10]2([CH2:12][CH2:11]2)[CH2:9][CH:8]1[C:15]([NH:17][C:18]1([C:21]2[CH:30]=[CH:29][C:24]([C:25]([O:27]C)=[O:26])=[CH:23][CH:22]=2)[CH2:20][CH2:19]1)=[O:16].O[Li].O>>[F:34][C:2]([F:1])([F:35])[C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][CH:33]=1)[CH2:6][N:7]1[CH2:14][CH2:13][C:10]2([CH2:12][CH2:11]2)[CH2:9][CH:8]1[C:15]([NH:17][C:18]1([C:21]2[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:29][CH:30]=2)[CH2:19][CH2:20]1)=[O:16]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186223HCID 71186223, compound

Product 1

HCID 71186491HCID 71186491, compoundYield 66.2%

Procedure

The title compound (E9) (39 mg) was prepared according to the general procedure for esters hydrolysis (Method D) starting from methyl 4-(1-(6-(3-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoate (single unknown enantiomer) (D125) (60.7 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-8e8d17651c794028ab33783fb100a383
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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