Lithium hydroxide, monohydrate → HCID 71186331, compound

HRID 712902Notes

Reaction equation

HRID 712902 reaction equation
[CH3:1][C:2]1([C:21]([NH:23][C@H:24]([C:26]2[CH:35]=[CH:34][C:29]([C:30]([O:32]C)=[O:31])=[CH:28][CH:27]=2)[CH3:25])=[O:22])[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[CH2:8][CH2:7][C:4]2([CH2:6][CH2:5]2)[CH2:3]1.O[Li].O>>[CH3:1][C:2]1([C:21]([NH:23][C@H:24]([C:26]2[CH:27]=[CH:28][C:29]([C:30]([OH:32])=[O:31])=[CH:34][CH:35]=2)[CH3:25])=[O:22])[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:15][CH:16]=2)[CH2:8][CH2:7][C:4]2([CH2:6][CH2:5]2)[CH2:3]1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186580HCID 71186580, compound

Product 1

HCID 71186331HCID 71186331, compoundYield 24.4%

Procedure

The title compound (E11) (4.5 mg) was prepared according to the general procedure for esters hydrolysis (Method B) starting from methyl 4-((1S)-1-(5-methyl-6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)ethyl)benzoate (D130) (19 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-7b12062bf90a4a90aa1e97acc07c926f
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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