Lithium hydroxide, monohydrate → HCID 71186208, compound

HRID 712903Notes

Reaction equation

HRID 712903 reaction equation
[CH3:1][C:2]1([CH3:35])[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:4]([C:19]([NH:21][C:22]2([C:25]3[CH:34]=[CH:33][C:28]([C:29]([O:31]C)=[O:30])=[CH:27][CH:26]=3)[CH2:24][CH2:23]2)=[O:20])[CH2:3]1.O[Li].O>>[CH3:1][C:2]1([CH3:35])[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=2)[CH:4]([C:19]([NH:21][C:22]2([C:25]3[CH:26]=[CH:27][C:28]([C:29]([OH:31])=[O:30])=[CH:33][CH:34]=3)[CH2:24][CH2:23]2)=[O:20])[CH2:3]1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186492HCID 71186492, compound

Product 1

HCID 71186208HCID 71186208, compoundYield 64.5%

Procedure

The title compound (E12) (88.4 mg) was prepared according to the general procedure for esters hydrolysis (Method C) starting from methyl 4-(1-(4,4-dimethyl-1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (enantiomer 2) (D131 b) (141 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-dc82b365163947c4ae4ef58812446a1a
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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