Lithium hydroxide, monohydrate → HCID 71204694, compound

HRID 712906Notes

Reaction equation

HRID 712906 reaction equation
[F:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[C@@H:4]([C:19]([NH:21][C:22]2([C:25]3[CH:34]=[CH:33][C:28]([C:29]([O:31]C)=[O:30])=[CH:27][CH:26]=3)[CH2:24][CH2:23]2)=[O:20])[CH2:3]1.O[Li].O>>[F:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:16])[F:17])=[CH:11][CH:10]=2)[C@@H:4]([C:19]([NH:21][C:22]2([C:25]3[CH:26]=[CH:27][C:28]([C:29]([OH:31])=[O:30])=[CH:33][CH:34]=3)[CH2:23][CH2:24]2)=[O:20])[CH2:3]1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204702HCID 71204702, compound

Product 1

HCID 71204694HCID 71204694, compoundYield 65.1%

Procedure

The title compound (E15) (15.8 mg) was prepared according to the general procedure for esters hydrolysis (Method D) starting from methyl 4-(1-((2R)-4-fluoro-1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D134) (25 mg). (LiOH H2O: 4 eq; reaction time: 5 hrs)

Sources & evidence

ORD record
ord-5af9e533bfcf44109d961b8a22ec0e1d
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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