Lithium hydroxide, monohydrate → HCID 71204738, compound

HRID 712913Notes

Reaction equation

HRID 712913 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[C@@H:14]([C:15]([NH:17][C@H:18]([C:20]3[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][CH:21]=3)[CH3:19])=[O:16])[CH2:13][CH2:12][CH:11]3[CH:9]2[CH2:10]3)=[CH:5][CH:4]=1.O[Li].O>>[F:32][C:2]([F:1])([F:33])[C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[C@@H:14]([C:15]([NH:17][C@H:18]([C:20]3[CH:21]=[CH:22][C:23]([C:24]([OH:26])=[O:25])=[CH:28][CH:29]=3)[CH3:19])=[O:16])[CH2:13][CH2:12][CH:11]3[CH:9]2[CH2:10]3)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204732HCID 71204732, compound

Product 1

HCID 71204738HCID 71204738, compoundYield 74.3%

Procedure

The title compound (E26) (7.2 mg) was prepared according to the general procedure for esters hydrolysis (Method D) starting from methyl 4-((1S)-1-((3R)-2-(4-(trifluoromethyl)benzyl)-2-azabicyclo[4.1.0]heptane-3-carboxamido)ethyl)benzoate (diastereoisomers mixture) (D143) (10 mg). (LiOH H2O: 4 eq; reaction time: 10 hrs)

Sources & evidence

ORD record
ord-9c0f5d59f49a4c46957aa1cd5d9cf5ff
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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