Lithium hydroxide, monohydrate → HCID 71204676, compound

HRID 712916Notes

Reaction equation

HRID 712916 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[C@@H:13]([C:14]([NH:16][C:17]3([C:20]4[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][CH:21]=4)[CH2:19][CH2:18]3)=[O:15])[CH2:12][CH:11]3[CH:9]2[CH2:10]3)=[CH:5][CH:4]=1.O[Li].O>>[F:33][C:2]([F:1])([F:32])[C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[C@@H:13]([C:14]([NH:16][C:17]3([C:20]4[CH:29]=[CH:28][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=4)[CH2:18][CH2:19]3)=[O:15])[CH2:12][CH:11]3[CH:9]2[CH2:10]3)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 117966734HCID 117966734, compound

Product 1

HCID 71204676HCID 71204676, compoundYield 47.5%

Procedure

The title compound (E31) (46 mg) was prepared according to the general procedure for esters hydrolysis (Method C) starting from methyl 4-(1-((3R)-2-(4-(trifluoromethyl)benzyl)-2-azabicyclo[3.1.0]hexane-3-carboxamido)cyclopropyl)benzoate (diastereoisomer 2) (D148) (100 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-019baa74392e45d1848f0261509ff564
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

Loading…