Lithium hydroxide, monohydrate → HCID 71186598, compound

HRID 712920Notes

Reaction equation

HRID 712920 reaction equation
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:28]=[CH:27][C:6]([CH2:7][N:8]2[CH2:11][CH2:10][CH:9]2[C:12]([NH:14][C@H:15]([C:17]2[CH:26]=[CH:25][C:20]([C:21]([O:23]C)=[O:22])=[CH:19][CH:18]=2)[CH3:16])=[O:13])=[CH:5][CH:4]=1.O[Li].O>>[F:29][C:2]([F:1])([F:30])[C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[CH2:11][CH2:10][CH:9]2[C:12]([NH:14][C@H:15]([C:17]2[CH:18]=[CH:19][C:20]([C:21]([OH:23])=[O:22])=[CH:25][CH:26]=2)[CH3:16])=[O:13])=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71186323HCID 71186323, compound

Product 1

HCID 71186598HCID 71186598, compoundYield 29.6%

Procedure

The title compound (E36) (2 mg) was prepared according to the general procedure for esters hydrolysis (Method C) starting from methyl 4-((1S)-1-(1-(4-(trifluoromethyl)benzyl)azetidine-2-carboxamido)ethyl)benzoate (diastereoisomer 2) (D152b) (7 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs)

Sources & evidence

ORD record
ord-f7dbc893c2e047ce8d63b236ca22ec58
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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