Lithium hydroxide, monohydrate → HCID 117966823, compound

HRID 712924Notes

Reaction equation

HRID 712924 reaction equation
[CH3:1][C@:2]1([C:19]([NH:21][C:22]2([C:25]3[CH:34]=[CH:33][C:28]([C:29]([O:31]C)=[O:30])=[CH:27][CH:26]=3)[CH2:24][CH2:23]2)=[O:20])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1.O[Li].O>>[CH3:1][C@:2]1([C:19]([NH:21][C:22]2([C:25]3[CH:26]=[CH:27][C:28]([C:29]([OH:31])=[O:30])=[CH:33][CH:34]=3)[CH2:23][CH2:24]2)=[O:20])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([F:18])([F:16])[F:17])=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 71204695HCID 71204695, compound

Product 1

HCID 117966823HCID 117966823, compoundYield 80.4%

Procedure

The title compound (E41) (3.9 mg) was prepared according to the general procedure for esters hydrolysis (Method C) starting from (R)-methyl 4-(1-(2-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D157) (5 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs).

Sources & evidence

ORD record
ord-c02771017fe64673bffce54a12c6a5cd
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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