Lithium hydroxide, monohydrate → HCID 71186440, compound

HRID 712925Notes

Reaction equation

HRID 712925 reaction equation
[CH3:1][C@:2]1([C:18]([NH:20][C:21]2([C:24]3[CH:33]=[CH:32][C:27]([C:28]([O:30]C)=[O:29])=[CH:26][CH:25]=3)[CH2:23][CH2:22]2)=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1.O[Li].O>>[CH3:1][C@:2]1([C:18]([NH:20][C:21]2([C:24]3[CH:25]=[CH:26][C:27]([C:28]([OH:30])=[O:29])=[CH:32][CH:33]=3)[CH2:22][CH2:23]2)=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 117966817HCID 117966817, compound

Product 1

HCID 71186440HCID 71186440, compoundYield 88.9%

Procedure

The title compound (E43) (11.2 mg) was prepared according to the general procedure for esters hydrolysis (Method D) starting from (R)-methyl 4-(1-(2-methyl-1-(4-(trifluoromethyl)benzyl)pyrrolidine-2-carboxamido)cyclopropyl)benzoate (D159) (13 mg). (LiOH H2O: 4 eq; reaction time: 18 hrs).

Sources & evidence

ORD record
ord-98760c02dfd64065a9c821fae1a732a1
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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