反应详情

温度

65 °C

To (4-isopropoxy-3-methoxy-phenyl)-[8-[(4-methoxyphenyl)methyl]-9-phenyl-11-oxa-3,8-diazaspiro[5.5]undecan-3-yl]methanone (175 mg, 0.32 mmol), Pd(OH)2 (129 mg, 0.9186 mmol) and ammonium formate (405 mg, 6.43 mmol) was added ethanol. The reaction mixture was then heated at 65° C. for 16 hours. The reaction mixture was filtered, the solvent evaporated and the residue was purified by silica gel column chromatography using 0 to 60% EtOAc in hexanes as eluent to give (4-isopropoxy-3-methoxy-phenyl)-(9-phenyl-11-oxa-3,8-diazaspiro[5.5]undecan-3-yl)methanone. ESI-MS m/z calc. 424.5. found 425.5 (M+1)1; Retention time: 1.28 minutes (3 min run).

1. filtrationThe reaction mixture was filtered
2. customthe solvent evaporated
3. customthe residue was purified by silica gel column chromatography