反应详情

温度

70 °C

A mixture of piperazine (26.5 g, 308 mmol) in THF (350 mL) was heated to 70° C. and 1-(chloromethyl)-2,4-difluorobenzene (5 g, 30.8 mmol) was added. The suspension was heated at 70° C. overnight. The solid (piperazine) was filtered off, and the solvent was removed under reduced pressure. The residue was partitioned between EtOAc and water. The organic layer was dried and concentrated to give the title compound (6 g, 92%). ESI-MS m/z [M+H]+ 213.04.

1. temperatureThe suspension was heated at 70° C. overnight
2. filtrationThe solid (piperazine) was filtered off
3. customthe solvent was removed under reduced pressure
4. customThe residue was partitioned between EtOAc and water
5. customThe organic layer was dried
6. concentrationconcentrated