反应详情

温度

200 °C

Selenium dioxide (2.25 g, 20.3 mmol) was added to a solution of 7-(trans-4-tert-Butyl-cyclohexyloxy)-3-methyl-isoquinoline (2.01 g, 6.76 mmol) in Diphenyl ether (50 mL, 300 mmol) and the mixture was heated at 200° C. in a sealed tube for 4 hours. The reaction was then cooled to room temperature. Silica gel was added and the flask was placed in a cold water bath to solidify the diphenylether solvent. This solid mixture containing the crude product was purified by flash chromatography (0-30% EtOAc in hexanes) to give the title compound in 50% yield. ESI-MS(M+H+): 312.27.

1. temperatureThe reaction was then cooled to room temperature
2. additionSilica gel was added
3. customthe flask was placed in a cold water bath
4. customwas purified by flash chromatography (0-30% EtOAc in hexanes)