Acetyl chloride → HCID 84772608, compound

HRID 713965Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:11]([O-])=O)=[C:7]([CH:10]=1)[CH:8]=[O:9].O.O.O.[C:17]([O-])(=[O:19])[CH3:18].[Na+].C(OCC)(=O)C.C(N(CC)C(C)C)(C)C.C(Cl)(=O)C>[Pt](=O)=O>[CH:8]([C:7]1[CH:10]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=1[NH:11][C:17](=[O:19])[CH3:18])=[O:9]

Participants

Conditions

Temperature: -20 °C

Procedure

5-Methoxy-2-nitro-benzaldehyde (5.00 g, 0.0276 mol), Platinum dioxide (400 mg, 0.002 mol) and Sodium acetate trihydrate (300 mg, 0.002 mol) were placed in a pressure flask, followed by Ethyl acetate (200 mL, 2 mol). The reaction mixture was then purged under N2 at least 3 times, and H2 was introduced (purged 3 times) and maintained at 52 psi for 3 hours. The reaction mixture was then filtered, and cooled to at −20° C. N,N-Diisopropylethylamine (7.21 mL, 0.0414 mol) was added to the solution followed by Acetyl chloride (2.36 mL, 0.0331 mol). The reaction mixture was allowed to stir for 2 hours, and quenched with KHCO3 (sat). Organic layer was separated, and washed with waster, brine and dried over Na2SO4. Removal of solvent gave a crude product, which was then purified via chromatography (SiO2, 80 g, 0-100% ethyl acetate/hexanes; 4.28 g, 80%). 1H NMR (300 MHz, CHLOROFORM-d) δ ppm 2.25 (s, 3H) 3.88 (s, 3H) 7.10-7.26 (m, 2H) 8.69 (d, J=9.06 Hz, 1H) 9.90 (s, 1H) 10.75-11.04 (m, 1H). MS (ESI, M+1): 194.10.

Workup

customThe reaction mixture was then purged under N2 at least 3 times, and H2
additionwas introduced
custom(purged 3 times)
temperaturemaintained at 52 psi for 3 hours
filtrationThe reaction mixture was then filtered
customquenched with KHCO3 (sat)
customOrganic layer was separated
washwashed with waster, brine
dry with materialdried over Na2SO4
customRemoval of solvent

Sources & evidence

ORD record: ord-26e4cf30b6174972b038a9a8fa0c2227
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09186367B2

Reaction notes

Loading…